Enhanced Antibiotic Discovery by PROSPECTing
نویسندگان
چکیده
منابع مشابه
Antibiotic drug discovery
Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing dr...
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Experience is a valuable asset in scientific discovery. It enables the researcher to understandwhat has and has notworked in the past, and the way that problems can or should be addressed. However sometimes experience becomes enmired in dogma, and we must become careful as scientists not to think that what has been done previously is the only meaningful route forward. A strong object lesson is ...
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Antimicrobial drug resistance is a rising concern in the treatment of infectious diseases and necessitates the need for discovery of novel, potent antimicrobial compounds to combat antibiotic resistance. Since natural environment remains a potential source of novel antimicrobial products, this preliminary study was performed to test the potential of soils from Kericho County for antibiotic-prod...
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Certain glycolipid antigens for natural killer T (NKT) cells can direct the overall cytokine balance of the immune response. However, the molecular mechanism of Th1or Th2-biased cytokine secretion by NKT cells is still unknown. Previously, we synthesized isoglobotrihexosylceramide (iGb3) analogues by introducing a hydroxyl group at C4 on the ceramide portion of iGb3 to produce 4-HO-iGb3 or to f...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2019
ISSN: 0006-2960,1520-4995
DOI: 10.1021/acs.biochem.9b00616